MERTK/TYRO3  Polyclonal Antibody

Catalogue Numbers: BS61919-50, BS61919-100

Sizes: 50µl, 100µl

Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Swiss-Prot: Q12866/Q06418

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Receptor tyrosine kinases (RTKs) represent an important class of transmembrane signaling molecules. Binding of the extracellular domain of an RTK to its cognate ligand leads to receptor dimerization and the activation of the intrinsic tyrosine kinase activity of its intracellular kinase domain. The Axl/ UFO subfamily of receptor tyrosine kinases is comprised of members Tyro3 (also referred to as BYK, Brt, Dtk, RSE, Tif or Sky), Axl (also called Tyro7 or UFO) and Mer (also called Nyk, c-Eyk and Tyro12). Members of this family have a common molecular structure which contains an N-terminal extracellular domain comprised of two Ig domains, two FNIII domains and a membrane spanning single helix followed by the cytoplasmic tyrosine kinase domain. These RTKs are functionally significant in spermatogenesis, immunoregulation and phagocytosis. Tyro3, Axl and Mer are widely expressed in adult tissues with their expression most abundant in brain, testis, lymphatic and vascular tissue. Tyro3 has been shown to undergo posttranslational modifications including both tyrosine phosphorylation as well as glycosylation. Two proteins, protein S and Gas6, have been proposed as ligands for the Axl/UFO family of receptors. Both function as anti-coagulants through an unknown mechanism. Gas6 was cloned as a growth arrest-specific gene, while protein S is an abundant serum protein which is thought to act by indirectly inhibiting proteases involved in the coagulation response.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: MERTK/TYRO3 polyclonal antibody detects endogenous levels of MERTK/TYRO3 protein.

Extra Notes: Western blot (WB) analysis of MERTK/TYRO3 polyclonal antibody at 1:500 dilution
Lane1:A375 whole cell lysate(20ug)
Lane2:The Brain tissue lysate of Mouse(40ug)
Lane3:The Brain tissue lysate of Rat(40ug)

Bioworld Molecular Weight: ~ 110 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; MERTK; MER; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; TYRO3; BYK; DTK; RSE; SKY; TIF

Immunogen: Synthetic peptide, corresponding Human MERTK/TYRO3.

Conjugate: Unconjugated

Modification: Unmodified